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BAM-15 (preorder)

Name: BAM-15 (preorder)
Brand: Peptide Revolution
SKU: 8701
Price: 169 EUR
Availability: BackOrder
Rating: 5 (1 reviews)

Original price was: 199,00 €.Current price is: 169,00 €.

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Product Description

Research Peptide

BAM-15

BAM-15 is a research-grade mitochondrial protonophore uncoupler used exclusively for scientific investigation. It selectively disrupts mitochondrial membrane potential without affecting the plasma membrane, making it a valuable tool for metabolic and mitochondrial research.

Research Use Only

This product is intended strictly for laboratory and scientific investigation. Not for human consumption, therapeutic use, or veterinary application.

Specifications

Form

Research capsules

Content

50 mg BAM-15 per capsule, 60 capsules per bottle (3 g total)

Purity

≥ 99% (HPLC), third-party tested

Packaging

Sealed bottle with tamper-evident closure

Storage

Room temperature, dry, protected from light

Molecular Formula

C₁₆H₁₀F₂N₆O

Molecular Weight

≈ 340.29 g·mol⁻¹

IUPAC Name

N5,N6-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine

Other Names

BAM 15; furazano[3,4-b]pyrazine uncoupler

CAS Number

91713-92-5

Research Overview

BAM-15 is a furazano-pyrazine mitochondrial uncoupler that selectively transports protons across the mitochondrial inner membrane, dissipating the electrochemical gradient that drives ATP synthesis. Unlike traditional uncouplers such as DNP, BAM-15 does not depolarize the plasma membrane, thereby avoiding cardiovascular and thermogenic toxicities. Research demonstrates its efficacy in promoting weight loss and improving metabolic parameters in diet-induced obesity models without adverse effects on behavior or temperature regulation. Additional studies explore its potential in acute kidney injury, cancer metabolism, and aging-related neurodegeneration, positioning BAM-15 as a leading compound for mitochondrial uncoupling research.

Primary Research Areas

Mitochondrial Uncoupling Pharmacology

BAM-15 is the most selective mitochondrial protonophore available, surpassing traditional uncouplers for specificity and safety in mechanistic studies.

Obesity and Metabolic Disease

Demonstrates robust weight loss and improved glycemic control in animal models without thermogenic or cardiovascular toxicity.

Renal Ischemia and Acute Kidney Injury

Shows protective effects in ischemic and septic kidney injury models through mitochondrial reactive oxygen species reduction.

Cancer Metabolism Research

Investigated for its impact on mitochondrial vulnerabilities in tumor models, particularly triple-negative breast cancer.

Aging and Longevity

Extends lifespan and mitigates neurodegenerative phenotypes in invertebrate models, supporting studies on mitochondrial uncoupling and longevity.

Laboratory Handling Note

Handle BAM-15 under standard laboratory conditions, ensuring it is stored dry and protected from light. Use appropriate personal protective equipment and avoid any human or veterinary exposure.