SLU-PP-332 – 250mcg x 60 capsules

What is SLU-PP-332

SLU-PP-332 is a synthetic molecule developed as an agonist of the nuclear receptor REV-ERBα, which is involved in the regulation of biological clocks, lipid metabolism, glucose and inflammation. REV-ERB receptors are the target of research in the fields of sleep disorders, obesity, neurodegeneration and immunological reactions.

Effects investigated

• Anti-inflammatory effects: Suppression of cytokines such as IL-6 and TNF-α in inflammatory models.
• Support of circadian synchronization: Influences the expression of genes such as BMAL1, PER2 and CRY1.
• Reduction of fat mass: Improvement of lipid profile and insulin sensitivity observed.
• Neuroprotection: In preclinical studies, it has shown a positive effect on neuroinflammation.
• Potential in mood disorders: REV-ERB agonists are being investigated in the context of anxiety and depression.

How does SLU-PP-332 work?

SLU-PP-332 binds and activates the REV-ERBα receptor, thereby influencing the expression of genes associated with circadian rhythms, inflammatory pathways and metabolism. By activating this receptor, it can reduce the production of pro-inflammatory cytokines, improve insulin sensitivity and optimize energy expenditure. It is also thought to have an effect on neuroinflammation and behavioral models of anxiety.

Dosage in studies

• Dose: 100–300 mcg/kg per day (mainly in in vivo models)
• Form: oral (capsule form or solution)
• Frequency: 1× daily
• Duration: 10–28 days according to protocol

SLU-PP-332 is an investigational compound that is a selective agonist of the REV-ERBα receptor, which plays a role in the regulation of circadian rhythms, metabolism, and inflammatory processes. It is gaining attention in experimental models related to energy homeostasis, inflammation reduction, and neurodegeneration.