TAK-653 (Osavampator) 2 mg – 60 tablets

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Research Compound · Tablets

TAK-653 (Osavampator) 2 mg – 60 Tablets

Research-grade compound supplied as 60 pre-portioned tablets, each containing 2 mg TAK-653 (osavampator). A selective, non-desensitizing AMPA-receptor positive allosteric modulator (PAM) studied in controlled experimental models of glutamatergic signaling, synaptic plasticity, and rapid-acting antidepressant pharmacology.

Research Use Only
This product is intended strictly for laboratory and scientific investigation. Not for human consumption, therapeutic use, or veterinary application.

Specifications

Purity
≥99% (HPLC, third-party tested, CoA on file)
Form
Research tablets
Content per Tablet
2 mg TAK-653 (osavampator)
Total per Bottle
60 tablets (120 mg total)
Packaging
Sealed bottle with tamper-evident closure
Storage
Store at room temperature, dry, protected from light
Molecular Formula
C₁₉H₂₃N₃O₃S
Molecular Weight
≈ 373.47 g/mol
Synonyms
TAK-653; Osavampator; NBI-1065845
CAS Number
1358751-06-0

Format

Supplied as pre-portioned research tablets — no reconstitution or weighing is required, supporting consistent dosing accuracy in controlled experimental workflows. Keep the bottle sealed and stored at room temperature, dry and protected from light.

Research Overview

TAK-653 is a selective, non-desensitizing positive allosteric modulator of the AMPA subtype of ionotropic glutamate receptors, the principal mediator of fast excitatory neurotransmission in the mammalian brain. Unlike older AMPA potentiators, it was engineered to minimize agonistic activity while enhancing synaptic AMPA signaling in physiologically relevant ranges. In controlled experimental settings it is used as a reference compound for glutamatergic plasticity, cognition, and rapid-acting antidepressant mechanism research. No therapeutic or clinical claims are made or implied.

Primary Research Areas

AMPA-Receptor Positive Allosteric Modulation
A reference compound for selective, non-desensitizing AMPA signaling research in glutamatergic pharmacology models.
Rapid-Acting Antidepressant Mechanisms
Studied in experimental paradigms of non-NMDA, non-dissociative antidepressant-like pharmacology.
Glutamatergic Synaptic Plasticity
Applied in studies of long-term potentiation, BDNF release, and synaptogenesis in preclinical models.
Cognitive & Procognitive Research
Evaluated in working-memory and executive-function paradigms in experimental cohorts.
Translational PET Pharmacology
Investigated with AMPA-receptor PET imaging approaches for direct receptor-occupancy research.

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